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Worrisome Emergence of Pan-INSTI Resistance: A Systematic Scoping Review of Dolutegravir Resistance in INSTI-Naïve Patients Post-Therapy Failure

2025-02-02

Abstract excerpt

<h4>Introduction</h4> Dolutegravir (DTG), a second-generation integrase strand transfer inhibitor (INSTI), is widely used in HIV treatment, especially in low-resource settings. Despite its proven efficacy, concerns about DTG resistance mutations (DRMs) have emerged in patients failing dual NRTI + DTG-based ART regimens. This review examines the patterns and frequencies of these DRMs in INSTI-naïve patients. <h4>Me...

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Literature Corpus work
e6772777-51da-5fc1-b636-ee4e5ffb914d
DOI
10.1101/2025.02.01.25320414
Open publication

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Worrisome Emergence of Pan-INSTI Resistance: A Systematic Scoping Review of Dolutegravir Resistance in INSTI-Naïve Patients Post-Therapy FailureDOI 10.1101/2025.02.01.25320414
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