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Article

Sex differences in susceptibility to substance use disorder: Role for X chromosome inactivation and escape?

Molecular and cellular neurosciences - 1 Jun 2023

Krueger Kate, Lamenza Felipe, Gu Howard, El-Hodiri Heithem, Wester Jason, Oberdick John, Fischer Andy J, Oghumu Steve

Abstract excerpt

There is a sex-based disparity associated with substance use disorders (SUDs) as demonstrated by clinical and preclinical studies. Females are known to escalate from initial drug use to compulsive drug-taking behavior (telescoping) more rapidly, and experience greater negative withdrawal effects than males. Although these biological differences have largely been attributed to sex hormones, there is evidence for...

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Identifiers

PMID: 37207894
DOI: 10.1016/j.mcn.2023.103859
PMCID: PMC10286730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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