Article
Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India).
Molecular genetics and genomics : MGG - 1 Jul 2023
Sharma Sadhana, Kumari Bandana, Ali Asgar, Patel Pankaj Kumar, Sharma Abhay Kumar, Nair Rathish, Singh Prabhat Kumar, Hajela Krishnan
Abstract excerpt
The study aimed to measure plasma levels of Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) and their polymorphisms in COVID-19 patients and controls to detect association. As MBL is a protein of immunological importance, it may contribute to the first-line host defence against SARS-CoV-2. MBL initiates the lectin pathway of complement activation with help of MASP-1 and MASP-2. Hence,...
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