Article
Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children.
Molecular biology reports - 1 Jul 2023
Yilmaz Dilek, Soyoz Mustafa, Sahin Aslıhan, Cerci-Alkac Burcu, Karahan-Coven Hatice Ilayhan, Ekemen-Keles Yıldız, Ustundag Gulnihan, Kara-Aksay Ahu, Yilmaz Nisel, Pirim İbrahim
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) is a member of innate immunity and acts with MASP (MBL-associated serine protease) to activate the lectin pathway of the complement system. MBL gene polymorphisms are associated with susceptibility to infectious diseases. This study investigated whether MBL2 genotype, serum MBL levels, and serum MASP-2 levels affect the course of SARS-CoV-2 infection. METHODS AND RESULTS:...
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