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Article

Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies.

The Biochemical journal - 17 Apr 2020

Leemans Margaux, Galicia Christian, Deyaert Egon, Daems Elise, Krause Linda, Paesmans Jone, Pardon Els, Steyaert Jan, Kortholt Arjan, Sobott Frank, Klostermeier Dagmar, Versées Wim

Abstract excerpt

Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on the design of LRRK2 kinase inhibitors. We recently showed that the central RocCOR domains (Roc: Ras of complex proteins; COR: C-terminal of Roc) of a bacterial LRRK2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32167135
DOI: 10.1042/BCJ20190843
PMCID: PMC7135905

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Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies.PMID 32167135Read ↗

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