Article
Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis.
Cancer gene therapy - 1 Aug 2023
Cômes Pierre-Cyril, Le Van Tuan, Tran Suzanne, Huard Solène, Abi-Jaoude Samiya, Venot Quitterie, Marijon Pauline, Boetto Julien, Blouin Antoine, Bielle Franck, Ducos Yohan, Teranishi Yu, Kalamarides Michel, Peyre Matthieu
Abstract excerpt
Despite their rarity, PIK3CA mutations in meningiomas have raised interest as potentially targetable, ubiquitous mutations owing to their presence in sporadic benign and malignant tumors but also in hormone-related cases. Using new genetically engineered mouse models, we here demonstrate that Pik3ca mutations in postnatal meningeal cells are sufficient to promote meningioma formation but also tumor progression in...
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