Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis

Abstract excerpt

<title>Abstract</title> <p>Despite their rarity, <italic>PIK3CA</italic> mutations in meningiomas have raised interest as potentially targetable, ubiquitous mutations owing to their presence in sporadic benign and malignant tumors but also in hormone-related cases. Using new genetically engineered mouse models, we here demonstrate that <italic>Pik3ca</italic> mutations in post-natal meningeal cells are sufficient...

Topics

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• Aged
• Breast Neoplasms
• Cell Transformation, Neoplastic
• Class I Phosphatidylinositol 3-Kinases
• Meningeal Neoplasms
• Meningioma
• Mice
• Mutation

Identifiers and source

Literature Corpus work

087d1140-b1fc-5338-81b5-063f11e118a1

DOI

10.21203/rs.3.rs-2511823/v1