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Article

DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations.

Oncotarget - 27 Sept 2016

Abba Martín C, Zhong Yi, Lee Jaeho, Kil Hyunsuk, Lu Yue, Takata Yoko, Simper Melissa S, Gaddis Sally, Shen Jianjun, Aldaz C Marcelo

Abstract excerpt

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenzathracene (DMBA) and short latency tumors (65 ± 11 days) induced by the progestin Medroxyprogesterone Acetate (MPA)...

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Source

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Identifiers

PMID: 27588403
DOI: 10.18632/oncotarget.11733
PMCID: PMC5325442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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