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Article

Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models.

The American journal of pathology - 1 Jul 2024

Linscott Maryknoll P, Ren Jerry R, Gestl Shelley A, Gunther Edward J

Abstract excerpt

A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting that carcinogen-induced mutations generate long-lived premalignant clones. How subsequent events influence the progression of specific premalignant clones remains poorly understood. Herein, multistage mouse models of mammary carcinogenesis were generated by combining chemical carcinogen exposure [using...

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Identifiers

PMID: 38537934
DOI: 10.1016/j.ajpath.2024.02.018
PMCID: PMC11220927

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