Article
Progestin-associated shift of meningioma mutational landscape.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2018
Peyre M, Gaillard S, de Marcellus C, Giry M, Bielle F, Villa C, Boch A L, Loiseau H, Baussart B, Cazabat L, Raffin-Sanson M L, Sanson M, Kalamarides M
Abstract excerpt
Background: Meningiomas are the most common primary tumor of the central nervous system. The relationship between meningioma and progestins is frequently mentioned but has not been elucidated. Patients and methods: We identified 40 female patients operated for a meningioma after long-term progestin therapy and performed targeted next generation sequencing to decipher the mutational landscape of hormone-related...
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