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Article

Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations.

Biomolecules - 23 Apr 2019

Mitchell Camilla B, Phillips Wayne A

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth, metabolism, proliferation and survival. As a result, alterations in the PI3K pathway are frequently associated with human cancers. Indeed, PIK3CA-the gene encoding the p110α catalytic subunit of PI3K-is one of the most commonly mutated human oncogenes. PIK3CA mutations have also been...

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Identifiers

PMID: 31018529
DOI: 10.3390/biom9040158
PMCID: PMC6523081

Genes

PIK3CA

Provenance

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