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Article

Human SOD1 is secreted via a conventional secretion pathway in Saccharomyces cerevisiae.

Biochemical and biophysical research communications - 23 Jul 2023

Hosomi Akira, Okachi Chinatsu, Fujiwara Yudai

Abstract excerpt

Soluble proteins sorted through the secretory pathway contain an N-terminal signal peptide that induces their translocation into the endoplasmic reticulum (ER) from the cytosol. However, a few proteins that lack a signal peptide are still translocated into the ER, such as SOD1. SOD1 is a causative gene of amyotrophic lateral sclerosis (ALS). A relationship has been suggested between the secretion of SOD1 and the...

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Identifiers

PMID: 37182284
DOI: 10.1016/j.bbrc.2023.05.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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