Article
Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis.
Biochemical Society transactions - 1 Oct 2011
Bastow Emma L, Gourlay Campbell W, Tuite Mick F
Abstract excerpt
ALS (amyotrophic lateral sclerosis) is a fatal neurodegenerative disease attributable to the death of motor neurons. Associated with ALS are mutations in the genes encoding SOD1 (superoxide dismutase 1), FUS (fused in Sarcoma) protein and TDP-43 (TAR DNA-binding protein-43) each of which leads to aggregation of the respective protein. For example, the ALS-associated mutations in the hSOD1 (human SOD1) gene...
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