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Article

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis.

Journal of neurochemistry - 1 Apr 2014

Atkin Julie D, Farg Manal A, Soo Kai Ying, Walker Adam K, Halloran Mark, Turner Bradley J, Nagley Phillip, Horne Malcolm K

Abstract excerpt

Cu/Zn-superoxide dismutase is misfolded in familial and sporadic amyotrophic lateral sclerosis, but it is not clear how this triggers endoplasmic reticulum (ER) stress or other pathogenic processes. Here, we demonstrate that mutant SOD1 (mSOD1) is predominantly found in the cytoplasm in neuronal cells. Furthermore, we show that mSOD1 inhibits secretory protein transport from the ER to Golgi apparatus. ER-Golgi...

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Source

Identifiers

PMID: 24134191
DOI: 10.1111/jnc.12493

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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