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Article

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.

Cellular and molecular life sciences : CMLS - 1 Nov 2013

Sundaramoorthy Vinod, Walker Adam K, Yerbury Justin, Soo Kai Ying, Farg Manal A, Hoang Vy, Zeineddine Rafaa, Spencer Damian, Atkin Julie D

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disorder and the majority of ALS is sporadic, where misfolding and aggregation of Cu/Zn-superoxide dismutase (SOD1) is a feature shared with familial mutant-SOD1 cases. ALS is characterized by progressive neurospatial spread of pathology among motor neurons, and recently the transfer of extracellular, aggregated mutant SOD1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23765103
DOI: 10.1007/s00018-013-1385-2
PMCID: PMC11113712

Genes

SOD1

Provenance

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Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.PMID 23765103Read ↗

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