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Will polygenic risk scores for cancer ever be clinically useful?

21 May 2021

Abstract excerpt

Genome-wide association studies (GWAS) have identified associations between common genetic variants, single nucleotide polymorphisms (SNPs) and the risk of developing different cancers 1 , 2 , 3 . Proponents argue that polygenic risk score (PRS) testing, based on panels of risk SNPs, will revolutionize the prevention and early detection of cancer through individualised risk management strategies and streamlining...

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PMID: 34021222
DOI: 10.1038/s41698-021-00176-1

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