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Article

Terfenadine metabolism of human cytochrome P450 2J2 containing genetic variations (G312R, P351L and P115L).

Drug metabolism and pharmacokinetics - 1 Feb 2018

Jeong Dabin, Park Hyoung-Goo, Lim Young-Ran, Lee Yejin, Kim Vitchan, Cho Myung-A, Kim Donghak

Abstract excerpt

The human cytochrome P450 2J2 is involved in several metabolic reactions, including the oxidation of important therapeutics and epoxidation of endogenous arachidonic acid. At least ten genetic variations of P450 2J2 have been identified, but their effects on enzymatic activity have not been clearly characterized. Here, we evaluated the functional effects of three genetic variations of P450 2J2 (G312R, P351L, and...

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Source

Identifiers

PMID: 29223463
DOI: 10.1016/j.dmpk.2017.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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