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Article

The Role of Progranulin in Glioblastoma Progression and Tumor Microenvironment Modulation

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the most aggressive type of primary brain tumor and is characterized by its invasiveness, therapeutic resistance, and complex tumor microenvironment (TME). Progranulin (GRN), a secreted glycoprotein, has been implicated in promoting malignancy across various cancers, but its role in GBM remains underexplored. This study presents an investigation of the molecular an...

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Literature Corpus work
a03d58de-838f-5fc9-91b8-3c64a0a0ee60
DOI
10.21203/rs.3.rs-7403403/v1
Open publication

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