Article
Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells.
Cell communication and signaling : CCS - 2 Oct 2017
Oliveira Ana Isabel, Anjo Sandra I, Vieira de Castro Joana, Serra Sofia C, Salgado António J, Manadas Bruno, Costa Bruno M
Abstract excerpt
BACKGROUND: Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by establishing a complex network of interactions with tumor cells. In this context, we investigated how GBM cells modulate resident glial cells, particularly their paracrine activity, and how this...
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