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Article

Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation.

Scientific reports - 12 May 2023

Kristof Zsuliet, Gal Zsofia, Torok Dora, Eszlari Nora, Sutori Sara, Erdelyi-Hamza Berta, Petschner Peter, Sperlagh Beata, Anderson Ian M, Deakin John Francis William, Bagdy Gyorgy, Juhasz Gabriella, Gonda Xenia

Abstract excerpt

Emotional stress is a leading risk factor in the development of neuropsychiatric disorders possibly via immune activation. P2X7 receptors promote neuroinflammation, and research suggests a relationship between chromosome region 12q2431, in which the P2X7R gene is located, and development of mood disorders, however, few studies concentrate on its association with anxiety. Our aim was to investigate the effects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37173368
DOI: 10.1038/s41598-023-34781-w
PMCID: PMC10182087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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