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Article

Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk.

International journal of molecular sciences - 10 Jan 2024

Kristof Zsuliet, Gal Zsofia, Torok Dora, Eszlari Nora, Sutori Sara, Sperlagh Beata, Anderson Ian M, Deakin Bill, Bagdy Gyorgy, Juhasz Gabriella, Gonda Xenia

Abstract excerpt

Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors...

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Share to Adolescent and Pediatric Healthcare
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38255938
DOI: 10.3390/ijms25020865
PMCID: PMC10815854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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