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New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer

30 Apr 2024

Abstract excerpt

Epidermal growth factor (EGF)-EGF receptor (EGFR) signaling studies paved the way for a basic understanding of growth factor and oncogene signaling pathways and the development of tyrosine kinase inhibitors (TKIs). Due to resistance mutations and the activation of alternative pathways when cancer cells escape TKIs, highly diverse cell populations form in recurrent tumors through mechanisms that have not yet been...

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PMID: 38692865
DOI: 10.1248/bpb.b23-00924

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