Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Abstract excerpt

Recently, a study by Edwin Cuppen’s group published in Nature depicted the genomic differences between late-stage treated metastatic cancers and early-stage untreated primary cancers via a pan-cancer whole-genome sequencing (WGS) analysis. 1 This study characterizes unique features of metastatic solid tumors and provides a valuable resource for further investigating tumor evolution and treatment resistance.

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