Article
RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression Patterning Identifies ZNF44 Variants as a Potential New Driver Gene for Pediatric Neuroblastoma.
Cancer control : journal of the Moffitt Cancer Center - 1 Jan 2000
Sun Lan, Li Xiaoqing, Tu Lingli, Stucky Andres, Huang Chuan, Chen Xuelian, Cai Jin, Li Shengwen Calvin
Abstract excerpt
INTRODUCTION: Neuroblastoma (NB) is one of the children's most common solid tumors, accounting for approximately 8% of pediatric malignancies and 15% of childhood cancer deaths. Somatic mutations in several genes, such as ALK, have been associated with NB progression and can facilitate the discovery of novel therapeutic strategies. However, the differential expression of mutated and wild-type alleles on the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.