Article
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.
Neuro-oncology - 1 Jul 2017
Ramkissoon Shakti H, Bandopadhayay Pratiti, Hwang Jaeho, Ramkissoon Lori A, Greenwald Noah F, Schumacher Steven E, O'Rourke Ryan, Pinches Nathan, Ho Patricia, Malkin Hayley, Sinai Claire, Filbin Mariella, Plant Ashley, Bi Wenya Linda, Chang Michael S, Yang Edward, Wright Karen D, Manley Peter E, Ducar Matthew, Alexandrescu Sanda, Lidov Hart, Delalle Ivana, Goumnerova Liliana C, Church Alanna J, Janeway Katherine A, Harris Marian H, MacConaill Laura E, Folkerth Rebecca D, Lindeman Neal I, Stiles Charles D, Kieran Mark W, Ligon Azra H, Santagata Sandro, Dubuc Adrian M, Chi Susan N, Beroukhim Rameen, Ligon Keith L
Abstract excerpt
BACKGROUND: Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical pediatric oncology practice are not yet well established. METHODS: Profile is an institution-wide prospective clinical research initiative that uses targeted sequencing to identify targetable alterations in tumors. OncoPanel, a multiplexed targeted...
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