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Article

Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants.

PloS one - 1 Jan 2022

Przybyła Weronika, Gjersvoll Paulsen Kirsti Marie, Mishra Charitra Kumar, Nygård Ståle, Engebretsen Solveig, Ruud Ellen, Trøen Gunhild, Beiske Klaus, Baumbusch Lars Oliver

Abstract excerpt

Neuroblastoma (NBL), one of the main death-causing cancers in children, is known for its remarkable genetic heterogeneity and varied patient outcome spanning from spontaneous regression to widespread disease. Specific copy number variations and single gene rearrangements have been proven to be associated with biological behavior and prognosis; however, there is still an unmet need to enlarge the existing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36037157
DOI: 10.1371/journal.pone.0273280
PMCID: PMC9423626

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