Article
Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.
Scientific reports - 19 Dec 2017
Miller Aubrey L, Garcia Patrick L, Pressey Joseph G, Beierle Elizabeth A, Kelly David R, Crossman David K, Council Leona N, Daniel Richard, Watts Raymond G, Cramer Stuart L, Yoon Karina J
Abstract excerpt
Neuroblastoma is a pediatric tumor characterized by histologic heterogeneity, and accounts for ~15% of childhood deaths from cancer. The five-year survival for patients with high-risk stage 4 disease has not improved in two decades. We used whole exome sequencing (WES) to identify mutations present in three independent high-risk stage 4 neuroblastoma tumors (COA/UAB-3, COA/UAB -6 and COA/UAB -8) and a stage 3...
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