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Article

Next generation sequencing identifies novel gene alterations with potential prognostic relevance in pediatric cancer: a single-center study.

The oncologist - 10 Apr 2026

Ma Yuhan, Su Mingwei, Liu Xiaoshan, Wang Wenxia, Wu Yu, Wang Zhixuan, Peng Xiaomin, Xiong Xilin, Lei Jiaying, Li Yang

Abstract excerpt

BACKGROUND: Next generation sequencing (NGS) has driven the development of precision oncology. While adult cancer genomics has been extensively studied, pediatric cancer, particularly among Asian populations, has received less attention. METHODS: We screened gene alteration profiles of 99 pediatric cancer patients using the targeted NGS panel and compared the results with those from Western cohorts. The...

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Source

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Identifiers

PMID: 42010939
DOI: 10.1093/oncolo/oyag147
PMCID: PMC13134386

Genes

KMT2D
DICER1
MYCN
TP53
ARID1B
EGFR
SFPQ
TACC1
TCF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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