Article
HLA-Clus: HLA class I clustering based on 3D structure.
BMC bioinformatics - 9 May 2023
Shen Yue, Parks Jerry M, Smith Jeremy C
Abstract excerpt
BACKGROUND: In a previous paper, we classified populated HLA class I alleles into supertypes and subtypes based on the similarity of 3D landscape of peptide binding grooves, using newly defined structure distance metric and hierarchical clustering approach. Compared to other approaches, our method achieves higher correlation with peptide binding specificity, intra-cluster similarity (cohesion), and robustness....
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