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Article

Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt-Jakob disease with codon 129VV genotype faithfully propagate in vivo.

Acta neuropathologica communications - 25 Mar 2021

Cali Ignazio, Espinosa Juan Carlos, Nemani Satish K, Marin-Moreno Alba, Camacho Manuel V, Aslam Rabail, Kitamoto Tetsuyuki, Appleby Brian S, Torres Juan Maria, Gambetti Pierluigi

Abstract excerpt

Current classifications of sporadic Creutzfeldt-Jakob disease (sCJD) identify five subtypes associated with different disease phenotypes. Most of these histopathological phenotypes (histotypes) co-distribute with distinct pairings of methionine (M)/valine (V) genotypes at codon 129 of the prion protein (PrP) gene and the type (1 or 2) of the disease-associated PrP (PrPD). Types 1 and 2 are defined by the...

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PMID: 33766126
DOI: 10.1186/s40478-021-01132-7
PMCID: PMC7995586

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