Article

Comparative analysis of kidney organoid and adult human kidney single cell and single nucleus transcriptomes

2017-12-11

Abstract excerpt

Kidney organoids differentiated from human pluripotent stem cells hold great promise for understanding organogenesis, modeling disease and ultimately as a source of replacement tissue. Realizing the full potential of this technology will require better differentiation strategies based upon knowledge of the cellular diversity and differentiation state of all cells within these organoids. Here we analyze single cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0256c02e-559d-5ba0-8469-54706f848af8
DOI: 10.1101/232561

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis of kidney organoid and adult human kidney single cell and single nucleus transcriptomesDOI 10.1101/232561Read

An Integrated Atlas of the Human Kidney Spanning Health and DiseasesSemantic proximity Read

Single-cell analysis reveals congruence between kidney organoids and human fetal kidneySemantic proximity Read

Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencingSemantic proximity Read

A single-cell multiomic analysis of kidney organoid differentiationSemantic proximity Read

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell TranscriptomicsSemantic proximity Read

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidneySemantic proximity Read

Kidney organoid reproducibility across multiple human iPSC lines and diminished off target cells after transplantation revealed by single cell transcriptomicsSemantic proximity Read

Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fateSemantic proximity Read

High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidneySemantic proximity Read

Organoid single-cell profiling identifies a transcriptional signature of glomerular diseaseSemantic proximity Read

Organoid single cell profiling identifies a transcriptional signature of glomerular diseaseSemantic proximity Read

An atlas of healthy and injured cell states and niches in the human kidneySemantic proximity Read