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Application of Ovarian Cancer Organoids in Precision Medicine: Key Challenges and Current Opportunities

2 Aug 2021

Abstract excerpt

Ovarian cancer (OC) is the leading cause of death among gynecologic malignances. Over the past decades, human-derived models have advanced from monolayer cell cultures to three-dimensional (3D) organoids that could faithfully recapitulate biological characteristics and tumor heterogeneity of primary tissues. As a complement of previous studies based on cell lines or xenografts, organoids provide a 3D platform for...

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PMID: 34409036
DOI: 10.3389/fcell.2021.701429

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