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Article

Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner.

The Journal of biological chemistry - 1 Jun 2023

Wu Yifei, Li Jincheng, Li Chenmeijie, Lu Shuai, Wei Xiaoyu, Li Yang, Xia Wenjuan, Qian Chunfeng, Wang Zihang, Liu Mingxi, Gu Yayun, Huang Boxian, Tan Yueqiu, Hu Zhibin

Abstract excerpt

N6-methyladenosine (m6A) is the most prevalent reversible RNA modification in the mammalian transcriptome. It has recently been demonstrated that m6A is crucial for male germline development. Fat mass and obesity-associated factor (FTO), a known m6A demethylase, is widely expressed in human and mouse tissues and is involved in manifold biological processes and human diseases. However, the function of FTO in...

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Identifiers

PMID: 37146971
DOI: 10.1016/j.jbc.2023.104783
PMCID: PMC10248873

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