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Unmasking the Epigenome: Insights into Testicular Cell Dynamics and Reproductive Function

28 Jul 2025

Abstract excerpt

The epigenetic landscape plays a pivotal role in regulating the functions of both germ and somatic cells (Sertoli and Leydig cells) within the testis, which are essential for male fertility. While somatic cells support germ cell maturation and testosterone synthesis, the epigenetic regulation of germ cells is critical for proper spermatogenesis and function. Epigenetic modifications such as DNA methylation,...

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PMID: 40806437
DOI: 10.3390/ijms26157305

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