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CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

5 May 2023

Abstract excerpt

Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein (ZAP), and so in principle, removing ZAP sensing from a virus propagation system will reverse attenuation of a...

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PMID: 37146066
DOI: 10.1371/journal.ppat.1011357

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