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Article

Use of a small DNA virus model to investigate mechanisms of CpG dinucleotide-induced attenuation of virus replication.

The Journal of general virology - 1 Nov 2020

Loew Lisa, Goonawardane Niluka, Ratcliff Jeremy, Nguyen Dung, Simmonds Peter

Abstract excerpt

Suppression of the CpG dinucleotide is widespread in RNA viruses infecting vertebrates and plants, and in the genomes of retroviruses and small mammalian DNA viruses. The functional basis for CpG suppression in the latter was investigated through the construction of mutants of the parvovirus, minute virus of mice (MVM) with increased CpG or TpA dinucleotides in the VP gene. CpG-high mutants displayed...

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Identifiers

PMID: 32783803
DOI: 10.1099/jgv.0.001477
PMCID: PMC7879557

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