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The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by <i>Culex</i> mosquitoes and pathogenesis in a vertebrate host

2025-01-22

Abstract excerpt

Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein coding RNA. Synonymously recoding viral genomes to introduce CpG or UpA dinucleotides has emerged as an approach for viral attenuation and vaccine development. However, studies that investi...

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Literature Corpus work
d5d93d86-2e1c-5388-8afa-c7db56160405
DOI
10.1101/2025.01.22.634234
Open publication

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