Article
Understanding off-target growth defects introduced to influenza A virus by synonymous recoding.
RNA (New York, N.Y.) - 16 Oct 2025
Sharp Colin P, Thompson Beth H, Hoque Ananya Ferdous, Diebold Ola, Tesla Blanka, Kurian Dominic, Simmonds Peter, Digard Paul, Gaunt Eleanor
Abstract excerpt
CpG dinucleotides are underrepresented in the genomes of most RNA viruses. Synonymously increasing CpG content of a range of RNA virus genomes reliably causes replication defects due to the recognition of CpG motifs in RNA by cellular zinc-finger antiviral protein (ZAP). Prior to the discovery of ZAP as a CpG sensor, we described an engineered influenza A virus (IAV) enriched for CpGs in segment 5 that displays...
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