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Article

Computational Modeling to Determine the Effect of Phenotypic Heterogeneity in Tumors on the Collective Tumor-Immune Interactions.

Bulletin of mathematical biology - 4 May 2023

Zhang Yuyuan, Wang Kaiqun, Du Yaoyao, Yang Huiyuan, Jia Guanjie, Huang Di, Chen Weiyi, Shan Yanhu

Abstract excerpt

Tumor immunotherapy aims to maintain or enhance the killing capability of CD8+ T cells to clear tumor cells. The tumor-immune interactions affect the function of CD8+ T cells. However, the effect of phenotype heterogeneity of a tumor mass on the collective tumor-immune interactions is insufficiently investigated. We developed the cellular-level computational model based on the principle of cellular Potts model to...

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Identifiers

PMID: 37142885
DOI: 10.1007/s11538-023-01158-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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