Article
A kinetic model of multiple phenotypic states for breast cancer cells.
Scientific reports - 29 Aug 2017
Qiu Kang, Gao Kai-Fu, Yang Li-Jian, Zhang Zhao-Kang, Wang Ran, Ma Hui-Shu, Jia Ya
Abstract excerpt
Quantitative modeling of microscopic genes regulatory mechanisms in an individual cell is a crucial step towards understanding various macroscopic physiological phenomena of cell populations. Based on the regulatory mechanisms of genes zeb1 and cdh1 in the growth and development of breast cancer cells, we propose a kinetic model at the level of single cell. By constructing the effective landscape of underlying...
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