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Targeting the Proteostasis Network for Mycobacterial Drug Discovery

21 Feb 2018

Abstract excerpt

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of therapy. During infection, Mtb encounters numerous stresses associated with host immunity, including hypoxia, reactive oxygen and nitrogen species, mild acidity, nutrient starvation, and metal...

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Biochemical and Molecular Research
RNA and protein synthesis mechanisms
Tuberculosis Research and Epidemiology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29465983
DOI: 10.1021/acsinfecdis.7b00231

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