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Article

An Inducible Chaperone Adapts Proteasome Assembly to Stress

17 Jul 2014

Abstract excerpt

The proteasome is essential for the selective degradation of most cellular proteins. To survive overwhelming demands on the proteasome arising during environmental stresses, cells increase proteasome abundance. Proteasome assembly is known to be complex. How stressed cells overcome this vital challenge is unknown. In an unbiased suppressor screen aimed at rescuing the defects of a yeast Rpt6 thermosensitive...

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PMID: 25042801
DOI: 10.1016/j.molcel.2014.06.017

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