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Article

Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways.

The Journal of cell biology - 1 Sept 2025

Dennison Devon D, Baldridge Ryan D

Abstract excerpt

Cellular protein quality control consists of multiple, networked systems that survey and maintain a healthy eukaryotic proteome. In Saccharomyces cerevisiae, the transmembrane ubiquitin ligase 1 (Tul1) complex is an integral membrane protein quality control system that functions within the Golgi-endosomal system. Golgi-localized Tul1 complexes target proteins for degradation by either the cytosolic proteasome or...

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Identifiers

PMID: 40694054
DOI: 10.1083/jcb.202312133
PMCID: PMC12282583

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