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The genetic puzzle of rheumatoid arthritis: Causes, progression, and treatment

21 Jul 2025

Abstract excerpt

Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and progressive joint destruction, influenced by a complex interplay of genetic and environmental factors. Substantial evidence highlights a significant genetic contribution to RA pathogenesis, with key genetic risk factors including human leukocyte antigen (HLA) genes and non-HLA variants. These genetic elements...

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PMID: 40734997
DOI: 10.1016/j.bbrep.2025.102148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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