Article
NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas.
Cancer research - 15 Sept 2017
Su Xiaoping, Zhang Jianping, Mouawad Roger, Compérat Eva, Rouprêt Morgan, Allanic Frederick, Parra Jérôme, Bitker Marc-Olivier, Thompson Erika J, Gowrishankar Banumathy, Houldsworth Jane, Weinstein John N, Tost Jorg, Broom Bradley M, Khayat David, Spano Jean-Philippe, Tannir Nizar M, Malouf Gabriel G
Abstract excerpt
Extensive dysregulation of chromatin-modifying genes in clear cell renal cell carcinoma (ccRCC) has been uncovered through next-generation sequencing. However, a scientific understanding of the cross-talk between epigenetic and genomic aberrations remains limited. Here we identify three ccRCC epigenetic clusters, including a clear cell CpG island methylator phenotype (C-CIMP) subgroup associated with promoter...
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