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Article

Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf.

The FEBS journal - 1 Mar 2018

Luchinat Enrico, Chiarella Sara, Franceschini Mimma, Di Matteo Adele, Brunori Maurizio, Banci Lucia, Federici Luca

Abstract excerpt

The tumor suppressor p14arf interacts, in response to oncogenic signals, with the p53 E3-ubiquitin ligase HDM2, thereby resulting in p53 stabilization and activation. In addition, it also exerts tumor-suppressive functions in p53-independent contexts. The activities of p14arf are regulated by the nucleolar chaperone nucleophosmin (NPM1), which controls its levels and cellular localization. In acute myeloid...

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Share to Molecular Targeted Therapy
Share to Nuclear Magnetic Resonance, Biomolecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleophosmin

Share to Protein Aggregates

Share to Protein Interaction Domains and Motifs

Share to Protein Interaction Mapping

Share to Spectrometry, Fluorescence

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 29283500
DOI: 10.1111/febs.14373

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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