Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitofilin Heterozygote Mice Display an Increase in Myocardial Injury and Inflammation after Ischemia/Reperfusion

13 Apr 2023

Abstract excerpt

Mitochondrial inner membrane protein (Mitofilin/Mic60) is part of a big complex that constituent the mitochondrial inner membrane organizing system (MINOS), which plays a critical role in maintaining mitochondrial architecture and function. We recently showed that Mitofilin physically binds to Cyclophilin D, and disruption of this interaction promotes the opening of mitochondrial permeability transition pore...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cardiac Ischemia and Reperfusion
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37107296
DOI: 10.3390/antiox12040921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitofilin Heterozygote Mice Display an Increase in Myocardial Injury and Inflammation after Ischemia/ReperfusionPMID 37107296Read ↗

Mic60/Mitofilin Inhibitor, Miclxin, Induces Rat H9C2 Cardiomyoblast Death by Inhibiting the Removal of Damaged MitochondriaSemantic proximity Read ↗

Mitochondrial fission process 1 (MTFP1) controls bioenergetic efficiency and prevents inflammatory cardiomyopathy and heart failure in miceSemantic proximity Read ↗

Inducible genetic ablation of <i>Immt</i> induces a lethal disruption of the MICOS complexSemantic proximity Read ↗

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.Semantic proximity Read ↗

Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1Semantic proximity Read ↗

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injurySemantic proximity Read ↗

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac FunctionSemantic proximity Read ↗

Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domainSemantic proximity Read ↗

Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domainsSemantic proximity Read ↗

Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.Semantic proximity Read ↗

Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.Semantic proximity Read ↗

Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.