Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.

doi:10.1074/jbc.M115.665695

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Article

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.

The Journal of biological chemistry - 23 Oct 2015

Cahill Thomas J, Leo Vincenzo, Kelly Matthew, Stockenhuber Alexander, Kennedy Nolan W, Bao Leyuan, Cereghetti Grazia M, Harper Andrew R, Czibik Gabor, Liao Chunyan, Bellahcene Mohamed, Steeples Violetta, Ghaffari Safar, Yavari Arash, Mayer Alice, Poulton Joanna, Ferguson David J P, Scorrano Luca, Hettiarachchi Nishani T, Peers Chris, Boyle John, Hill R Blake, Simmons Alison, Watkins Hugh, Dear T Neil, Ashrafian Houman

Abstract excerpt

We have reported previously that a missense mutation in the mitochondrial fission gene Dynamin-related protein 1 (Drp1) underlies the Python mouse model of monogenic dilated cardiomyopathy. The aim of this study was to investigate the consequences of the C452F mutation on Drp1 protein function and to define the cellular sequelae leading to heart failure in the Python monogenic dilated cardiomyopathy model. We...

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PMID: 26370078
DOI: 10.1074/jbc.M115.665695
PMCID: PMC4646246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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