Mic60/Mitofilin Inhibitor, Miclxin, Induces Rat H9C2 Cardiomyoblast Death by Inhibiting the Removal of Damaged Mitochondria

Abstract excerpt

Mitochondrial dysfunction is a hallmark in a variety of disease conditions, including ischemia/reperfusion (I/R) injury, stroke, and myocardial infarction (MI), metabolic syndrome, and aging. As with all biological organelles, the function of mitochondria is tightly linked with their structure. The inner mitochondrial membrane is a highly regulated, large surface area membrane that hosts the electron transport cha...

Topics

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• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cardiac Imaging and Diagnostics
• Cardiac Ischemia and Reperfusion
• Inflammasome and immune disorders
• Mitochondrial Function and Pathology
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

e37a093b-245c-548d-a02a-be473ce063c3

DOI

10.20944/preprints202505.0737.v1