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Article

Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.

Journal of cellular physiology - 1 Sept 2010

Mun Ji Young, Lee Tae Hoon, Kim Ji Hui, Yoo Bum Ho, Bahk Young Yil, Koo Hyeon-Sook, Han Sung Sik

Abstract excerpt

Human mitofilin is a mitochondrial protein that controls cristae formation. Here, we investigated the role of the Caenorhabditis elegans mitofilin homologs, IMMT-1 and -2, in reproduction, physiology, and mitochondrial cristae formation. Mutation of either immt-1 or immt-2 produced defects in germline development and egg-laying. These defects were exacerbated by the double mutation, which greatly reduced...

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PMID: 20578245
DOI: 10.1002/jcp.22177

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IMMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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